Items are arranged in order of publication date.
Please click on the "PDF" buttons to download the files.
[ Clinical Trials | Drug Development | Drug Resistance | Immunology ]
[ Pathology | Reviews | Tumor Biology | Stem Cell Purging | Detection of MRD ]
| Clinical Trials | |
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"Allogeneic Versus Autologous Purged Bone Marrow Transplantation for Neuroblastoma : A Report from the Childrens Cancer Group" - By Katherine K. Matthay, Robert C. Seeger, C. Patrick Reynolds, Daniel O. Stram, Maura C. O'Leary, Richard E. Harris, Michael Selch, James B. Atkinson, Gerald M. Haase and Norma K. Ramsay Journal of Clinical Oncology, Vol 12, No 11 (November) 1994: pp 2382-2389 This file is about 1.2 megabytes in size and may take up to 30 minutes or more to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. If it is more convenient, you can also download this file in 7 parts (all are also PDF files) of 100-200kbs each : [ Part 1 ] [ Part 2 ] [ Part 3 ] [ Part 4 ] [ Part 5 ] [ Part 6 ] [ Part 7 ] |
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"Treatment of High-Risk Neuroblastoma with Intensive Chemotherapy, Radiotherapy, Autologous Bone Marrow Transplantation, and 13-cis-Retinoic Acid" - By Katherine K. Matthay, M.D., Judith G. Villablanca, M.D., Robert C. Seeger, M.D., Daniel O. Stram, Ph.D., Richard E. Harris, M.D., Norma K. Ramsay, M.D., Patrick Swift, M.D., Hiroyuki Shimada, M.D., C. Thomas Black, M.D., Garrett M. Brodeur, M.D., Robert B. Gerbing, M.A., and C. Patrick Reynolds, M.D.,Ph.D., for the Children's Cancer Group New England Journal of Medicine, October 14, 1999. |
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"Biologic Variables in the Outcome of Stages I and II Neuroblastoma Treated with Surgery as Primary Therapy: A Children's Cancer Group Study" - By Carlos A. Perez, Katherine K. Matthay, James B. Atkinson, Robert C. Seeger, Hiroyuki Shimada, Gerald M. Haase, Daniel O. Stram, Robert B. Gerbing, and John N. Lukens J Clin Oncol, Vol 18, No 1(January), 2000:18-26. This file is about 74 kb in size and should take less than 1 minute to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
| Drug Development | |
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"Lytic Bone Lesions in Human Neuroblastoma Xenograft Involve Osteoclast Recruitment and Are Inhibited by Bisphosphonate" by Yasuyoshi Sohara, Hiroyuki Shimada, Miriam Scadeng, Harvey Pollack, Shinya Yamada, Wei Ye, C. Patrick Reynolds, and Yves A. DeClerck, Cancer Research, 63, 3026–3031, June 15, 2003 This file is about 640 kb in size and may take 5 minutes or less to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Increase of Ceramide and Induction of Mixed Apoptosis/Necrosis by N-(4-Hydroxyphenyl)-retinamide in Neuroblastoma Cell Lines" by Barry J. Maurer, Leonid S. Metelitsa, Robert C. Seeger, Myles C. Cabot, C. Patrick Reynolds, Journal of the National Cancer Institute, Vol. 91, No. 13, July 7, 1999, Reports, pp 1138 - 1146 This file is about 1 megabyte in size and may take 10 minutes or more to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Depletion of Glutathione by Buthionine Sulfoximine is Cytotoxic for Human Neuroblastoma Cell Lines via Apoptosis" by Clarke Paul Anderson, Janice M. Tsai, William E. Meek, Rui-Ming Liu, Yongmin Tang, Henry Jay Forman and C. Patrick Reynolds, Experimental Cell Research 246, 183-192 (1999). This file is about 214 kb in size and should take less than 5 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Synergistic cytotoxicity in solid tumor cell lines between N-(4-Hydroxyphenyl)retinamide and modulators of ceramide metabolism" by Maurer BJ, Melton L, Billups C, Cabot MC, Reynolds CP, J Natl Cancer Inst, 92:1897-1908, 2000. |
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"Retinoic-acid resistant neuroblastoma cell lines show altered myc regulation and high sensitivity to fenretinide" by Reynolds CP, Wang Y, Melton LJ, Einhorn PA, Slamon DJ, Maurer BJ, Medical Pediatric Oncology, 35:597-602, 2000. |
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"Synergism of buthionine sulfoximine and melphalan against neuroblastoma cell lines derived after disease progression" by Anderson, CP, Keshelava N, Satake N, Meek WH, Reynolds CP, Medical Pediatric Oncololgy, 35:659-662, 2000. |
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"Is there a role for retinoids in therapy of minimal residual disease in neuroblastoma?" by Matthay KK and Reynolds CP, Br J Cancer, 83:1121-1123, 2000. This file is about 50 kb in size and should take less than 1 minute to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Buthionine Sulfoximine and Myeloablative Concentrations of Melphalan Overcome Resistance in a Melphalan-Resistant Neuroblastoma Cell Line" by Clarke P. Anderson, M.D., Robert C. Seeger, M.D., Noriko Satake, M.D., Hector L. Monforte-Munoz, M.D., Nino Keshelava, M.D., Howard H. Bailey, M.D., and C. Patrick Reynolds, M.D., Ph.D.Journal of Pediatric Hematology/Oncology, 500-505, Vol. 23, No. 8, November 2001. This file is about 180 kb in size and may take 1-2 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
| Drug Resistance | |
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"Drug Resistance Patterns of Human Neuroblastoma Cell Lines Derived from Patients at Different Phases of Therapy" by Nino Keshelava, Robert C. Seeger, Susan Groshen, and C. Patrick Reynolds, in : Cancer Research, 58:5396-5405, December 1, 1998. This file is about 2 megabytes in size and may take 10-20 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Cross-resistance of topoisomerase I and II inhibitors in neuroblastoma cell lines" by Keshelava N, Groshen S, Reynolds CP, Cancer Chemotherapy and Pharmacology, 45:1-8, 2000. This file is about 180 kb in size and should take 1-2 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"p53 mutations and loss of p53 function confer multi-drug resistance in neuroblastoma" by Keshelava N, Zuo JJ, Waidyaratne NS, Triche TJ, Reynolds CP, Medical Pediatric Oncology, 35:563-568, 2000. |
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"Multidrug resistance-associated protein 1 (MRP1) expression in neuroblastoma cell lines and primary tumors" by Goto H., Choi MR, Keshelava N, Reynolds CP, in : Medical Pediatric Oncology, 35:619-622, 2000. This file is about 100 kb in size and should take 1-2 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Loss of p53 Function Confers High-Level Multidrug Resistance in Neuroblastoma Cell Lines" by Nino Keshelava, Juan J. Zuo, Ping Chen, Sitara N. Waidyaratne, Marian C. Luna, Charles J. Gomer, Timothy J. Triche, and C. Patrick Reynolds, in : Cancer Research, 61, 6185–6193, August 15, 2001. This file is about 240 kb in size and should take 1-2 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
| Immunology | |
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"Neutrophils are cytotoxic and growth inhibiting for neuroblastoma cells with anti-GD2 antibody but without cytotoxicity can be growth stimulating" by Chen RL, Reynolds CP, Seeger RC, Clinical Immunol Immunother, 48:603-612, 2000. This file is about 180 kb in size and should take 5-10 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
| Pathology | |
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"The International Neuroblastoma Pathology Classification (the Shimada System)", by Hiroyuki Shimada, M.D., Ph.D., Inge M. Ambros, M.D., Louis P. Dehner, M.D., Jun-ichi Hata, M.D., Vijay V. Joshi, M.D., Borghild Roald, M.D., Daniel O. Stram, Ph.D., Robert B. Gerbing, M.A., John N. Lukens, M.D., Katherine K. Matthay, M.D., Robert P. Castleberry, M.D., in : Cancer, July 15, 1999; Vol. 86 Number 2, pp 364-72. This file is about 95 kb in size and should take less than 1 minute to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Histopathology Defines Prognostic Subsets of Ganglioneuroblastoma, Nodular - A Report from the Children’s Cancer Group", by Shunsuke Umehara, M.D., Atsuko Nakagawa, M.D., Katherine K. Matthay, M.D., John N. Lukens, M.D., Robert C. Seeger, M.D., Daniel O. Stram, Ph.D., Robert B. Gerbing, M.A., Hiroyuki Shimada, M.D., Ph.D., in : Cancer, September 1, 2000, Volume 89, Number 5, pp 1150-1161. This file is about 1,400 kb in size and may take 20 minutes - 1 hour to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Histopathology (International Neuroblastoma Pathology Classification) and MYCN Status in Patients with Peripheral Neuroblastic Tumors", by Shoko Goto, M.D., Shunsuke Umehara, M.D., Robert B. Gerbing, M.A., Daniel O. Stram, Ph.D., Garrett M. Brodeur, M.D., Robert C. Seeger, M.D., John N. Lukens, M.D., Katherine K. Matthay, M.D., and Hiroyuki Shimada, M.D., Ph.D., in : Cancer, November 15, 2001, Volume92, Number 10, pp 2699-2708. This file is about 165 kb in size and may take 1-2 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
| Reviews | |
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"Treatment of High-Risk Solid Tumors of Childhood with Intensive Therapy and Autologous Bone Marrow Transplantation" by Robert C. Seeger, MD and C. Patrick Reynolds, MD, PhD. In : Pediatric Clinics of North America - Vol. 38, No. 2, April 1991, pp 393-424. This file is about 4 megabytes in size and may take up to 2 hours or more to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. If it is more convenient, you can also download this file in 7 parts (all are also PDF files) of 500-600kbs each : [ Part 1 ] [ Part 2 ] [ Part 3 ] [ Part 4] [ Part 5 ] [ Part 6 ] [ Part 7 ] |
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"Molecular Biology of Neuroblastoma", by John M. Maris and Katherine K. Matthay, in : J Clin Oncol, Vol 17, No 7 (July), 1999, pp 2264-2279. This file is about 400 kb in size and should take 2-3 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Hematopoietic Cell Transplantation for Neuroblastomas" by Robert C. Seeger and C. Patrick Reynolds, Hematopoietic Cell Transplantation, Second Edition, 1999. This file is about 2.8 megabytes in size and may take up to 1.5 hours or more to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. If it is more convenient, you can also download this file in 4 parts (all are also PDF files) of 500-800kbs each : [ Part 1 ] [ Part 2 ] [ Part 3 ] [ Part 4 ] |
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"Intensification of therapy using hematopoietic stem-cell support for high-risk neuroblastoma", by Katherine K. Matthay, in : Pediatr Transplantation, 1999: 3, suppl. 1: 72-77. This file is about 75 kb in size and should take 1-2 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Is there a role for retinoids in therapy of minimal residual disease in neuroblastoma?" by Matthay KK and Reynolds CP, Br J Cancer 83:1121-1123, 2000. |
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"Retinoid Therapy of neuroblastoma" by Reynolds CP and Lie, S, Neuroblastoma, Brodeur GM, Sawada T, Tsuchida Y, and Voute PA, eds., Elseviere Science, Amsterdam, pp 519-540, 2000. This file is about 2.7 megabytes in size and may take 30-60 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Differentiating agents in pediatric malignancies: Retinoids in Neuroblastoma" by Reynolds CP, Seeger CP, Current Oncology Reports, 2:511-518, 2000. This file is about 1.2 megabytes in size and may take 5-15 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Chapter 79, Neuroblastoma", by C. Patrick Reynolds and Robert C. Seeger, In : Cancer Treatment, Fifth Edition, pp1214-1236, 2000 This file is about 5.1 megabytes in size and may take up to 2 hours or more to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. If it is more convenient, you can also download this file in 7 parts (all are also PDF files) of 300-900kbs each : [ Part 1 ] [ Part 2 ] [ Part 3 ] [ Part 4 ] [ Part 5 ] [ Part 6 ] [ Part 7 ] |
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"Telomerase as a biological and prognostic marker in neuroblastoma" by Hiyama E and Reynolds CP, in : Neuroblastoma, Brodeur GM, Sawada T, Tsuchida Y, and Voute PA, eds., Elseviere Science, Amsterdam, pp 159-174, 2000. This file will be available for download in the near future. |
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"Detection of Minimal Residual Disease in Bone Marrow During or After Therapy as a Prognostic Marker for High-Risk Neuroblastoma" by C. Patrick Reynolds, MD PhD & Robert C. Seeger, MD. Guest Commentary in : Journal of Pediatric Hematology/Oncology, Vol. 23, No. 3, March/April 2001 Issue, pp 150-152. This file is about 46 kb in size and should take less than 5 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Treating High-Risk Neuroblastoma at the Turn of the Century" by C. Patrick Reynolds, MD PhD & Beth Hasenauer, RN MS. In : Candlelighters Childhood Cancer Foundation Quarterly Newsletter, Spring 2001 Issue, pp 1, 5-6, 9. This file is about 486 kb in size and should take less than 5 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Ras and Seppuku in Neuroblastoma" by C. Patrick Reynolds, MD PhD in : Journal of the National Cancer Institute, Vol.94, No.5, March 6, 2002, pp 319-321. This file is about 25 kb in size and should take less than 1 minute to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Ceramide synthesis and metabolism as a target for cancer therapy" - By C. Patrick Reynolds, Barry J. Maurer, and Richard N. Kolesnick Cancer Letters, 206 (2004) : pp 169–180 This file is about 190 kbytes in size and should take 5 minutes or less to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
| Tumor Biology | |
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"Differential Gene Expression Profiles Between Neuroblastomas With High Telomerase Activity and Low Telomerase Activity" - By Eiso Hiyama, Keiko Hiyama, Masahiko Nishiyama, C. Partrick Reynolds, Jerry W. Shay, and Takashi Yokoyama Journal of Pediatric Surgery, Vol 38, No 12 (December), 2003: pp 1730-1734 This file is about 75 kbytes in size and should take less than 1 minute to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Expression profiling of favorable and unfavorable neuroblastomas" - By Eiso Hiyama, Keiko Hiyama, Hiroaki Yamaoka, Taijiro Sueda, C. Patrick Reynolds, and Takashi Yokoyama Pediatr Surg Int, (2004) 20: pp 33–38 This file is about 400 kbytes in size and should take 5 minutes or less to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Telomerase activity by TRAP assay and telomerase RNA (hTR) expression are predictive of outcome in neuroblastoma", by Choi MR, Kim NW, Amshey S, Zuo JJ, Gerbing R, Stram D, Lukens JN, Matthay KK, Seeger RC, Reynolds CP, in : Medical Pediatric Oncology, 35:647-650, 2000. This file is about 100 kb in size and should take 1-2 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
| Detection of Minimal Residual Disease | |
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"Expression of Protein Gene Product 9.5 and Tyrosine Hydroxylase in Childhood Small Round Cell Tumors", by Yinglin Wang, Peggy Einhorn, Timothy J. Triche, Robert C. Seeger, and C. Patrick Reynolds, in : Clinical Cancer Research, February 2000, Vol. 6, pp551-558. This file is about 1.5 megabytes in size and may take 10-20 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
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"Quantitative Tumor Cell Content of Bone Marrow and Blood as a Predictor of Outcome in Stage IV Neuroblastoma: A Children’s Cancer Group Study" - By Robert C. Seeger, C.Patrick Reynolds, Richard Gallego, Daniel O. Stram, Robert B. Gerbing, and Katherine K. Matthay Journal of Clinical Oncology, Vol 18, No 24 (December 15), 2000: pp 4067-4076 |
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"Ganglioside GM2/GD2 Synthetase mRNA Is a Marker for Detection of Infrequent Neuroblastoma Cells in Bone Marrow", by Dave S. B. Hoon, Christine T. Kuo, Shenghua Wen, Hong Wang, Leonid Metelitsa, C. Patrick Reynolds, and Robert C. Seeger, in : AJP, August 2001, Vol. 159, No. 2. This file is about 120 kb in size and should take 1-2 minutes to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. |
| Stem Cell Purging | |
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"Model System for Removing Neuroblastoma Cells from Bone Marrow Using Monoclonal Antibodies and Magnetic Immunobeads" by C. Patrick Reynolds, Robert C. Seeger, Dai Dang Vo, Alfred T. Black, John Wells and John Ugelstad. In : Cancer Research 46, pp 5882-5886, November 1986 This file is about 1 megabyte in size and may take up to 30 minutes or more to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. If it is more convenient, you can also download this file in 2 parts (both are also PDF files) of about 500kbs each : [ Part 1 ] [ Part 2 ] |
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"Allogeneic Versus Autologous Purged Bone Marrow Transplantation for Neuroblastoma : A Report from the Childrens Cancer Group" - By Katherine K. Matthay, Robert C. Seeger, C. Patrick Reynolds, Daniel O. Stram, Maura C. O'Leary, Richard E. Harris, Michael Selch, James B. Atkinson, Gerald M. Haase and Norma K. Ramsay Journal of Clinical Oncology, Vol 12, No 11 (November) 1994: pp 2382-2389 This file is about 1.2 megabytes in size and may take up to 30 minutes or more to download on a 56kbps modem dialup connection. The download will be faster on a DSL, cable, ISDN, T1 or T3 connection. If it is more convenient, you can also download this file in 7 parts (all are also PDF files) of 100-200kbs each : [ Part 1 ] [ Part 2 ] [ Part 3 ] [ Part 4 ] [ Part 5 ] [ Part 6 ] [ Part 7 ] |
